Eight cases of necrotizing sialometaplasia of the parotid and submandibular glands are presented and added to six reported earlier by donath 1979. It is thought to be the result of an ischemic event of the vasculature supplying the salivary gland lobules. Necrotizing sialometaplasia is a benign, selflimiting and rare inflammatory disease of the minor salivary glands 16, which was first described as a distinct entity by abrams et al. Necrotizing sialometaplasia is a benign selflimiting disorder which can simulate malignancy. Although necrotizing sialometaplasia ns of the parotid gland is rare and occasionally presents as a lesion that mimics a malignant tumour, imaging findings in cases of ns have been rarely reported. The clinical and histopathologic features of necrotizing sialometaplasia often simulate those of malignancies such as squamous cell carcinoma or salivary gland malignancy. Summary necrotizing sialometaplasia is an uncommon in. Clinically and histologically necrotizing sialometaplasia may mimic malignant lesions. Necrotizing sialometaplasia ns is a selflimiting benign condition of unknown origin that affects mainly the minor salivary glands on the hard palate. Necrotizing sialometaplasia ns is an uncommon benign reactive necrotizing inflammatory process involving minor salivary.
Necrotizing sialometaplasia is a rare disease first described in 1973. Necrotizing sialometaplasia is a benign inflammatory process that involves the minor salivary glands, primarily those of the hard palate. Necrotizing sialometaplasia radiology reference article. A case of necrotizing sialometaplasia in a 37yearold man with clinical documentation on the. Pathology clinic necrotizing sialometaplasia lester dr thompson. An association with neoplasia, such as parotid tumors, false vocal cord squamous cell carcinoma, and maxillary sinus carcinoma, is also reported. Often painless, the condition is selflimiting and should heal in 610 weeks. Necrotizing sialometaplasia is a benign, selflimiting and rare. This page was last edited on 2 october 2019, at 08. This report presents a patient with ns who suffered from frequent bouts of vomiting subsequent to silastic ring vertical gastroplasty which resulted in remarkably low ph of the. Bilateral localization of necrotizing sialometaplasia.
Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or. Necrotizing sialometaplasia ns is a benign disease showing inflammatory response which occurs in minor salivary glands mimicking a malignant lesion both clinically as well as histopathologically. Necrotizing sialometaplasia a diagnostic conundrum. It is thought to be caused by ischemic necrosis death of tissue due to lack of blood supply of minor salivary glands in response to trauma. This relatively rare condition holds diagnostic importance because of its ambiguous clinical and histopathological presentation that can be misdiagnosed clinically as neoplasia. Craterlike ulcerated lesion of hard palate microscopic histologic description. The lesions are characterized histologically by an extensive necrosis of the salivary gland tissue together with squamous metaplasia of.
Necrotizing sialometaplasia, is a benign inflammatory lesion primarily involving the minor salivary glands of the hard palate. Physicians should be aware of its clinical and histological traits in order to avoid unnecessary disfiguring surgery. Classically, it involves the mucoserous glands of the hard palate. We report the case of a healthy 26yearold man with a painless swelling in the hard palate near the middle raphe, asymptomatic, well. Knowledge about the disease is required because it mimics malignant neoplasms on. A sheep in wolfsclothing healing as a diagnostic test robert b. Pdf necrotizing sialometaplasia ns is a selflimiting inflammatory disease, that involves salivary glands, more frequently the minor ones. In the above presented case, the patients history was suggestive of a malignant process. Knowledge about the disease is required because it mimics malignant neoplasms on clinical and histological examination, particularly squamous cell carcinoma and mucoepidermoid carcinoma 24.
Necrotizing sialometaplasia nsm is an uncommon inflammatory condition that affects salivary glands. Necrotizing sialometaplasia after silastic ring vertical. Case report open access necrotizing sialometaplasia as a. Necrotizing sialometaplasia was first described in 1973 by abrams, melrose and howell1. Necrotizing sialometaplasia was first reported to involve the minor salivary glands of the oral cavity, particularly those of the palate. Necrotising sialometaplasia appears to be a significant, but uncommon, cause of unilateral salivary gland disease in the cat. Necrotizing sialometaplasia free download as powerpoint presentation. Necrotizing sialometaplasia sialometaplasia was first. Necrotizing sialometaplasia is a rare, benign, selflimiting, necrotizing process involving the minor salivary glands, mainly the mucoserous glands of the hard palate. The major importance of this condition is the danger of misdiagnosis, because it may clinically and histologically mimic a malignancy. All structured data from the file and property namespaces is available under the creative commons cc0 license. Case report of necrotizing sialometaplasia med oral patol oral cir.
Necrotizing sialometaplasia print emedicine dermatology. By continuing to use our website, you are agreeing to our use of cookies. This article is from journal of medical case reports, volume 5. Necrotizing sialometaplasia nsm is a benign, selfhealing lesion of salivary glands, which represents less than 1% of biopsied oral lesions. Necrotizing sialometaplasia is a rare benign and selflimiting disease, which commonly affects the minor salivary glands. Necrotizing sialometaplasia and atheromatous emboli were present in the larynx five weeks after manipulation of an atherosclerotic aneurysm. Necrotizing sialometaplasia of the larynx secondary to. Acute necrotizing ulcerative gingivitis anug is a common, noncontagious infection of the gums with sudden onset. The lesion occurs due to vascular ischemia caused by trauma. Necrotizing sialometaplasia necrotizing sialometaplasias. Vollmer, md \sb\necrotizing sialometaplasia is a benign selflimited intraoral lesion that is easily confused both clinically and histologically with squamous cell carcinoma.
Some predisposing factors such as smoking, use of alcohol, denture wearing, recent surgery, traumatic injuries. It appears as an aggressive looking lesion in an adult possibly resembling squamous cell carcinoma and mucoepidermoid carcinoma. Necrotizing sialometaplasia as a cause of a nonulcerated nodule in. Patient 1 was a 23yearold woman who was referred for a slightly painful bilateral symmetric. Necrotizing sialometaplasia is a distinct, though rare disease of the salivary glands. Files are available under licenses specified on their description page. This selflimiting benign lesion is easily confused with malignant tumors. Necrotizing sialometaplasia is a benign selflimiting process that does not require specific treatment. Typically, it involves the seromucinous glands located at palate, buccal mucosa, tongue, tonsil, nasal cavity, trachea, larynx, maxillary sinus, and retromolar trigone. Necrotizing sialometaplasians is a benign, self limiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma both clinically and histologically and can lead to unnecessary surgical approach. Here we report a case of necrotizing sialometaplasia in a female on left side of hard palate mimicking carcinoma.
Histologically, there is necrosis of the mucous cells of the minor salivary gland tissue with partial replacement by squamous epithelium. The temp we use cookies to enhance your experience on our website. Reported cases of necrotizing sialometaplasia associated with bulimia. It predominantly affects salivary tissue and usually involves the palate, although it has. The aim of this article is to report a case of necrotizing sialometaplasia with longterm followup. Necrotizing sialometaplasia ns is a benign, ulcerative lesion, usually located towards the back of the hard palate. Necrotizing sialometaplasia wikipedia republished wiki 2. Sialometaplasia definition at, a free online dictionary with pronunciation, synonyms and translation. Sialometaplasia definition of sialometaplasia by medical. The main features are painful, bleeding gums, and ulceration of interdental papillae the sections of gum between adjacent teeth. Necrotizing sialometaplasia is a nonneoplastic, inflammatory, variably ulcerated, occasionally bilateral, selfhealing lesion of human salivary glands which is often confused clinically and. In 1973, abrams et al first reported this condition. Necrotizing sialometaplasia most commonly arises in the minor salivary glands of the hard palate. Case report of necrotizing sialometaplasia core reader.
Necrotizing sialometaplasia ns is a benign, self limiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma both clinically and histologically and can lead to unnecessary surgical approach. The lesion often presents itself as a deepseated palatal ulcer with. Necrotizing sialometaplasia is a benign inflammatory process that affects minor salivary and mucous glands of the oral cavity and nose and may histologically. Three weeks later after biopsy same patient in media. Necrotizing sialometaplasia is a benign, selflimiting and rare inflammatory disease which, on clinical and histological examination, mimics. Necrotizing sialometaplasia, oral ulcers, minor salivary. A case of necrotizing sialometaplasia ns is presented in a female patient, who initially presented as a suspected head and neck malignancy. Necrotizing sialometaplasia is an inflammatory, rare and benign pathology, affecting particularly minor salivary glands. A further five cases were reported the following year by dunlap and barker.
It presents as a painless ulceration, frequently on the hard palate, that. It is considered by some authors to be a distinct entity and by others to be part of the spectrum of necrotizing sialometaplasia ns. Major salivary glands have been rarely reported as sites of necrotizing sialometaplasia, a disease primarily affecting minor salivary tissue, particularly that of the palate. Necrotizing sialometaplasia is a selfhealing nonneoplastic disease of the hard and soft palate characterized by one. Necrotizing sialometaplasia is a rare, benign inflammatory disease of the minor mucous salivary glands usually caused by glandular ischemia or trauma, that can mimic malignancy, but has a selflimiting character. Necrotizing sialometaplasia ns is a nonneoplastic inflammatory condition of the salivary glands. In its clinical and histological appearance, it mimics malignancy. Seventyfive percent of all cases occur on the posterior palate. Most cases of necrotizing sialometaplasia appear to arise spontaneously, whereas others are associated with a history of trauma, vomiting, 18, 19 radiation therapy, or surgery. A 38yearold man with bilateral ulcerative painful lesions at the junction of. Spangler and culbertson 1991 report an incidence of % 1185 among cases of feline salivary gland disease while the cases reported here represent about 5% 242. Necrotizing sialometaplasia of hard palate a case report.
All subsequent reports of necrotizing sialometaplasia stress the. Necrotizing sialometaplasia wikipedia medicine a benign ulcerative lesion found mostly on the posterior hard palate, caused by a necrosis of minor salivary glands due to trauma. Necrotizing sialometaplasia international journal of. We describe here a case of ns in which there was an increasing lesion manifesting overnight on the parotid gland in an 83yearold male. Necrotizing sialometaplasia the journal of laryngology. Histologic findings in humans and dogs are identical, but the distribution of affected glands and clinical course are very different. Pseudoepitheliomatous hyperplasia squamous metaplasia of ducts and acini. Necrotizing sialometaplasia ns is a benign, selflimiting inflammatory reaction of salivary gland tissue which may mimic squamous cell carcinoma or mucoepidermoid carcinoma, both clinically and histologically, that creates diagnostic dilemma leading to unwarranted aggressive surgery. We present a 32yearold, white, male with rare bilateral localization of necrotizing sialometaplasia. Necrotizing sialometaplasia is a selfhealing nonneoplastic disease of the hard and soft palate characterized by one or two deeply excavating ulcers. Necrotizing sialometaplasia uncommon locally destructive inflammatory condition of the salivary glands.
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